Citation

Stylianou M, Proschan M, Flournoy N. Stat. Med. 2003; 22(4): 535-543.

Affiliation

Office of Biostatistics Research, National Heart, Lung, and Blood Institute/NIH, 6701 Rockledge Drive, Room 8220, Bethesda, MD 20892, U.S.A. StylianM@nih.gov

Copyright

(Copyright © 2003, John Wiley and Sons)

DOI

10.1002/sim.1351

PMID

12590412

Abstract

One of the most important aspects of a phase I trial or other acute toxicity study is estimating accurately the probability of toxicity that is associated with the recommended dose. We use the biased coin up-and-down design to allocate and isotonic regression to estimate toxicity probabilities and determine the recommended dose. We then derive, using bootstrap methods, an estimate of the probability of toxicity at the recommended dose. Small sample properties of this estimator are also evaluated. Published in 2003 by John Wiley & Sons, Ltd.

Language: en