Citation

Prasannan L, Flynn JT, Levine JE. Pediatr. Nephrol. 2003; 18(3): 283-285.

Affiliation

Division of Pediatric Hematology and Oncology, University of Michigan, Ann Arbor, MI 48106, USA. prasannan.latha@marshfieldclinic.org

Copyright

(Copyright © 2003, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s00467-002-1051-7

PMID

12644925

Abstract

A 17-year-old patient with sickle cell-beta thalassemia undergoing treatment with home iron chelation therapy inadvertently received ten times the recommended dose of intravenous deferoxamine. Acute renal failure (ARF) developed within hours. Immediate treatment with high-efficiency hemodialysis resulted in the prompt return of renal function after only one hemodialysis session. No long-term nephrotoxic effects of the deferoxamine overdose developed after more than 1 year of follow-up. Children with sickle cell disease who are on intravenous deferoxamine and their parents should be cautioned about the possibility of ARF with overdose due to malfunction of the pump and/or inadequate monitoring during treatment. ARF, should it occur in such children, appears to respond well to treatment with high-efficiency hemodialysis.

Language: en