Citation

Wirz-Justice A, Haug HJ, Cajochen C. Schizophr. Bull. 2001; 27(3): 497-502.

Affiliation

Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland. anna.wirz-justice@unibas.ch

Copyright

(Copyright © 2001, Maryland Psychiatric Research Center, Publisher Oxford University Press)

DOI

unavailable

PMID

11596850

Abstract

The circadian rest-activity cycle of schizophrenia patients stabilized for more than a year on monotherapy with a "classical" neuroleptic (haloperidol, flupentixol) or with the atypical neuroleptic clozapine was documented by continuous activity monitoring for 3-7 weeks. In this pilot study, the three patients treated with clozapine had remarkably highly ordered restactivity cycles, whereas the four patients on classical neuroleptics had minor to major circadian rhythm abnormalities. This is the first documentation of circadian rest-activity cycle disturbances in schizophrenia related to class of drug.

Language: en