Citation

Branger B, Peyrière H, Zabadani B, Vécina F, Abbar M. Nephrologie 2000; 21(6): 291-293.

Vernacular Title

Intoxication volontaire par les sels de lithium; risques de la forme retard.

Affiliation

Service de médecine C et de néphrologie, CHU, Nîmes.

Copyright

(Copyright © 2000, Médecine et Hygiène)

DOI

unavailable

PMID

11117108

Abstract

Lithium carbonate has been an invaluable drug in the treatment of manic-depressive illness. At the present time slow-release forms are available for better stability of circulating drug level with one daily take. However the better stability of lithiemia with these forms has to be balanced with a higher toxic risk in cases of lithium carbonate overdose because of continuous release. We report three cases of overdose with sustained-release lithium salts reaching life threatening complications. Two hemodialysis sessions were necessary to control plasma lithium levels. In two cases, lithiemia rebond was observed after the first hemodialysis session, and was associated with severe neurological disorders. This publication pointed out the therapeutic rule of at least two hemodialysis sessions in cases of severe slow release lithium carbonate salts intoxication.

Language: fr