Citation

Hanley NA, Bourke JP, Gascoigne AD. Intensive Care Med. 1998; 24(7): 740-742.

Affiliation

Intensive Therapy Unit, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK.

Copyright

(Copyright © 1998, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

9722048

Abstract

Flecainide acetate is a potent class Ic anti-arrhythmic drug with major sodium channel blocking actions. On the surface electrocardiogram this results in QTc interval prolongation. Overdose with class Ic drugs (< 0.1% of total intoxications) is uncommon, but management is difficult and the mortality high [1]. Serious flecainide overdose is characterised by ventricular tachyarrhythmias, severe bradycardia and variable degrees of atrioventricular block. This report describes a case of life-threatening flecainide overdose in a previously fit individual, resulting in a combination of cardiac disturbances. The treatment options and management are discussed.

Language: en