Citation

Nagamizu M, Komori Y, Uchiya K, Nikai T, Tu AT. Toxins (Basel) 2009; 1(2): 162-172.

Affiliation

Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan; Email: ykomori@ccmfs.meijo-u.ac.jp (Y.K.); kuchiya@ccmfs.meijo-u.ac.jp (K.U.); nikai@ccmfs.meijo-u.ac.jp (T.N.).

Copyright

(Copyright © 2009, MDPI: Multidisciplinary Digital Publishing Institute)

DOI

10.3390/toxins1020162

PMID

22069538

PMCID

PMC3202788

Abstract

SEA SNAKES (FAMILY: Hydrophiidae) are serpents found in the coastal areas of the Indian and Pacific Oceans. There are two subfamilies in Hydrophiidae: Hydrophiinae and Laticaudinae. A toxin, aagardi toxin, was isolated from the venom of the Hydrophiinae snake, Hydrophis torquatus aagardi and its chemical properties such as molecular weight, isoelectric point, importance of disulfide bonds, lack of enzymatic activity and amino acid sequence were determined. The amino acid sequence indicated a close relationship to the primary structure of other Hydrophiinae toxins and a significant difference from Laticaudinae toxins, confirming that primary toxin structure is closely related to sea snake phylogenecity.

Language: en