Citation

Brain PF, Evans CM. Physiol. Behav. 1975; 14(5): 551-556.

Copyright

(Copyright © 1975, Elsevier Publishing)

DOI

10.1016/0031-9384(75)90180-8

PMID

unavailable

Abstract

Neither isolated or group-housed intact adult female CFW strain mice displayed overt fighting or threat behavior during standard opponent behavioral tests. Neither testosterone nor androstenedione administered as daily oil based IM injections over 24 days markedly influenced overt fighting in adult ovariectomized females. However, testosterone administered in the form of SC 25 mg implants significantly increased overt fighting and threat behavior in ovariectomized females compared to sham-implanted mice over the same time interval. It was concluded that the aggressiveness of female mice of this strain could be significantly increased by androgen administration in adult life without previous neonatal hormonal manipulation, an effect in which the method of hormone administration appeared to be of critical importance. Some possible reasons for this result which is in conflict with most of the literature are suggested.