Citation

Aoki K, Yoshino A, Ueda Y, Urano T, Takada A. Burns 1998; 24(1): 74-77.

Affiliation

Department of Emergency Medicine, Hamamatsu University School of Medicine, Japan.

Copyright

(Copyright © 1998, Elsevier Publishing)

DOI

unavailable

PMID

9601597

Abstract

In a 38-year-old man, severe heat stroke caused disseminated intravascular coagulation (DIC) associated with significantly elevated plasma plasminogen activator inhibitor 1 levels. Investigation of the effects of hyperthermia on coagulation and fibrinolysis showed, in apparent conflict with previous reports, a time lag between the initial hypercoagulable and hyperfibrinolytic response (within 24 hr) and hypofibrinolysis shown by a disproportionate increase of PAI-1 (after 24 h), which possibly occurs in correspondence with the recovery of vascular endothelial integrity. The patient was discharged without sequelae although computed tomography (CT) scans indicated the likelihood of venous infarction or posterior inferior cerebellar artery area infarction secondary to DIC.

Language: en