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Citation |
Greven FE, Krop EJ, Spithoven JJ, Burger N, Rooyackers JM, Kerstjens HA, van der Heide S, Heederik DJ. Am. J. Ind. Med. 2012; 55(1): 54-62. |
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Affiliation |
Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; Department of Environmental Health, Municipal Health Services Groningen, Groningen, the Netherlands. f.greven@hvd.groningen.nl. |
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Copyright |
(Copyright © 2012, John Wiley and Sons) |
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DOI |
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PMID |
21959832 |
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Abstract |
BACKGROUND: Associations between acute respiratory inflammatory responses, changes in bronchial hyperresponsiveness, serum pneumoprotein levels, and exposure to fire smoke were studied. METHODS: The study comprised 51 firefighters. Blood samples were taken within 24 hr following exposure to fire smoke, and after a week and 3 months. Sputum was induced within 5 days post-exposure and subjects underwent spirometry and methacholine provocation one week post-exposure. Exposure was registered by a questionnaire. RESULTS: No changes were observed following smoke exposure in bronchial hyperresponsiveness and serum pneumoprotein levels. Nevertheless, in a sizable proportion of the firefighters (44%) elevated sputum neutrophil levels (≥60%) were found. Serum IL-8 concentrations were higher 24 hr post-exposure compared to pre-exposure. Elevated neutrophil levels in sputum were associated with elevated serum IL-8 (β = 0.010, P = 0.004) and TNFα (β = 0.005, P = 0.034) levels within 24 hr post-exposure and IL-8 elevation lasted up to 3 months. CONCLUSIONS: Acute exposure to fire smoke induces acute neutrophilic airway and long-lasting systemic inflammation in healthy firefighters in the absence of bronchial hyperresponsiveness. Am. J. Ind. Med. © 2011 Wiley Periodicals, Inc. Language: en |