Citation

Monje Argiles A, Lison D, Lauwerys R, Mahieu P, Brucher JM, Van den Bergh P. Acta Neurol. Belg. 1990; 90(4): 190-199.

Affiliation

Department of Neurology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Copyright

(Copyright © 1990, Acta Medica Belgica)

DOI

unavailable

PMID

2124029

Abstract

We report a patient in whom intoxication with a commercial preparation of malathion led to a severe acute cholinergic crisis, protracted cardiac arrhythmias, an acute respiratory distress syndrome, and an acute sensorimotor axonal polyneuropathy. The occurrence of the polyneuropathy was associated with a novel malathion transformation product, S-(1-ethoxycarbonyl, 2-isopropoxycarbonyl) ethyl 0,0-dimethyl phosphorodithioate (isopropylmalathion), an impurity present in the pesticide residue. The role of isopropylmalathion in the pathophysiology of the polyneuropathy remains to be determined.

Language: en