Citation

Salo M, Merikanto J, Eskola J, Nieminen S, Aho AJ. Acta Chir. Scand. 1979; 145(6): 367-372.

Copyright

(Copyright © 1979, Society for the Publication of Acta Chirurgica Scandinavica)

DOI

unavailable

PMID

525181

Abstract

The effect of accidental trauma on lymphocyte transformation induced by phytohaemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM) and purified protein derivative of tuberculin (PPD) was studied in 66 patients with minor, moderate or multiple trauma. An in vitro whole blood micromethod was used. The lymphocyte transformation induced by the mitogens and the antigen was impaired in patients with trauma in proportion to the severity of the injury. A decrease of lymphocytic responses to a very low level had prognostic value for the patient as indicated by the two patients with very low lymphocytic responses and serious infectious complications.

Language: en