Citation

Gentleman SM, Roberts GW, Gennarelli TA, Maxwell WL, Adams JH, Kerr S, Graham DI. Acta Neuropathol. 1995; 89(6): 537-543.

Affiliation

Department of Psychiatry, Charing Cross and Westminster Medical School, London, UK.

Copyright

(Copyright © 1995, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

7676809

Abstract

beta-Amyloid precursor protein immunostaining has recently been shown to be a reliable method for detecting the damage to axons associated with fatal head injury. In an attempt to compare the efficacy of this technique with conventional histological detection of axonal damage, we have reanalysed sections from a large well-characterised series of head-injured and control patients. The results indicate that the frequency of axonal injury has been vastly underestimated using conventional silver techniques, and that axonal injury may in fact be an almost universal consequence of fatal head injury.

Language: en