Citation

Plantamura J, Dorandeu F, Burnat P, Renard C. Ann. Pharm. Fr. 2011; 69(4): 196-200.

Vernacular Title

L'arsine : un toxique chimique industriel peu connu.

Affiliation

Département contrôle analytique, pharmacie centrale des armées, TSA 30004, 45404 Fleury-les-Aubrais cedex, France.

Copyright

(Copyright © 2011, Elsevier Publishing)

DOI

10.1016/j.pharma.2011.05.002

PMID

21840437

Abstract

Arsines family includes many compounds with various toxicities. Arsenic trihydride or arsine is the most toxic form of arsenic. Powerful haemolytic gas, it has never been used as a chemical weapon because its toxicity is not immediate and it is non persistent. However, cases of industrial poisoning with arsine are still identified in spite of a strict regulation at work. It is also identified as a potential toxic of chemical terrorism. This agent, of which the mechanism of action is still not well defined, is badly recognized because of intoxications rarity. However, fast detection means are available. Health professionals and especially those who are involved in piratox plan need to learn to recognize arsine intoxication (hematuria, oliguria, haemolytic anemia) in order to provide early, specific treatment and avoid damages.

Language: fr