Citation

Boereboom FT, van Dijk A, van Zoonen P, Meulenbelt J. J. Toxicol. Clin. Toxicol. 1998; 36(4): 345-352.

Affiliation

National Institute of Public Health and the Environment, Bilthoven, The Netherlands. FTJ.Boereboom@rivm.nl

Copyright

(Copyright © 1998, Marcel Dekker)

DOI

unavailable

PMID

9711201

Abstract

CASE REPORT: A case of nonaccidental endosulfan intoxication in a previously healthy 43-year-old male patient is reported. On admission, the patient had few symptoms, but refractory seizures began 1 hour after ingestion. The patient died on the fourth day after admission showing clinical signs of cerebral herniation confirmed at autopsy. Blood, urine, and tissue samples were analyzed for alpha-endosulfan, beta-endosulfan, and endosulfan sulfate by capillary gas chromatography with electron capture detection. Concentration versus time data for endosulfan were fitted using the program MW/Pharm, assuming complete bioavailability although it is recognized that the bioavailability of endosulfan after ingestion may have been low and the calculated clearance was primarily due to redistribution. Hemoperfusion was shown to be ineffective.

Language: en