Citation

Montoya-Cabrera MA, Escalante-Galindo P, Sauceda-García JM, Márquez-Enríquez LM, González-Cabello H, Flores-Alvarez E. Gac. Med. Mex. 1995; 131(3): 349-354.

Vernacular Title

El tratamiento de las intoxicaciones agudas causadas por carbamazepina, digoxina

Affiliation

Departamento de Urgencias y Toxicología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (IMSS).

Copyright

(Copyright © 1995, Academia Nacional De Medicina de Mexico)

DOI

unavailable

PMID

8582575

Abstract

Twelve pediatric patients with acute poisonings caused by carbamazepine, digoxin and acetylsalicylic acid were treated with multiple doses of activated charcoal combined with a saline cathartic (adsorption surface of activated charcoal nearly 950 m2/g). This procedure was effective to shorten the plasmatic levels of the drugs, besides the clinical improvement of the poisoned patients. The average initial and final levels of the drugs were: carbamazepine 21.64 and 0.9 micrograms/ml (lowering 95.81%, p < 0.05), digoxin 5.14 and 1.1 ng/ml (lowering 78.6%, P < 0.05) and acetylsalicylic acid 418.5 and 57.5 micrograms/ml, respectively, (lowering 86.3%, p < 0.05). These results suggest the usefulness of activated charcoal in the clearance of the four overdosed drugs.

Language: es