Citation

Tayag EC, Nair SN, Wahhab S, Katsetos CD, Lighthall JW, Lehmann JC. Brain Res. 1996; 733(2): 287-291.

Affiliation

Department of Neurosurgery, Medical College of Pennsylvania, Philadelphia 19102-1192, USA.

Copyright

(Copyright © 1996, International Brain Research Organization, Publisher Elsevier Publishing)

DOI

unavailable

PMID

8891312

Abstract

Following traumatic brain injury (TBI), cortical and thalamic areas were analyzed histologically and by high-performance liquid chromatography with electrochemical detection for uric acid at various survival times. Following TBI, cortical uric acid was elevated by ten-fold at 24 and 48 h, but not at 1 h post-TBI. Histological evidence of neurodegeneration was found not only in cortex but also in the anteroventral thalamus. These data suggest that as in stroke, uric acid measurements may be a convenient and sensitive method for measuring peroxidative status in TBI.

Language: en