Citation

Coccaro EF, Sripada CS, Yanowitch RN, Phan KL. Biol. Psychiatry 2011; 69(12): 1153-1159.

Affiliation

Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois.

Copyright

(Copyright © 2011, Elsevier Publishing)

DOI

10.1016/j.biopsych.2011.02.032

PMID

21531387

Abstract

Building on animal and human lesion evidence, neuroimaging studies are increasingly identifying abnormalities in corticolimbic circuits mediating aggressive behavior. This review focuses on three neural systems involved in impulsive/reactive aggression: 1) subcortical neural systems that support the production of aggressive impulses; 2) decision-making circuits and social-emotional information processing circuits that evaluate the consequences of aggressing or not aggressing; and 3) frontoparietal regions that are involved in regulating emotions and impulsive motivational urges. We review psychiatric disorders, including borderline personality disorder and antisocial personality disorder, characterized by elevated reactive aggression, focusing on abnormalities in these three neural systems.

Language: en