Citation

Nishikawa M, Diksic M, Sakai Y, Kumano H, Charney D, Palacios‐Boix J, Negrete J, Gill K. Alcohol Clin. Exp. Res. 2009; 33(2): 233-239.

Copyright

(Copyright © 2009, John Wiley and Sons)

DOI

10.1111/j.1530-0277.2008.00820.x

PMID

unavailable

Abstract

Background:  A consistent association between low endogenous 5HT function and high alcohol preference has been observed, and a number of serotonergic manipulations (uptake blockers, agonists) alter alcohol consumption in animals and humans. Studies have also shown an inverse relationship between alcohol use and cerebrospinal fluid levels of serotonin metabolites, suggesting that chronic alcohol consumption produces alterations in serotonin synthesis or release.