Citation

Weber WM, Kracko DA, Lehman MR, Cox CE, Cheng YS, Grotendorst GR, McDonald JD. Toxicol. Mech. Methods 2011; 21(7): 547-553.

Affiliation

Lovelace Respiratory Research Institute, Albuquerque, NM, USA.

Copyright

(Copyright © 2011, Informa Healthcare)

DOI

10.3109/15376516.2011.569774

PMID

21473735

Abstract

Sulfur mustard (SM) is a chemical threat agent for which the effects have no current treatment. Due to the ease of synthesis and dispersal of this material, the need to develop therapeutics is evident. The present article details the techniques used to develop SM laboratory exposure systems for the development of animal models of ocular and dermal injury. These models are critical to enable evaluation of SM injury and therapeutics against that injury. Iterative trials were conducted to optimize dermal and ocular injury models in guinea pigs and rabbits respectively. The goal was a homogeneous and diffuse ocular and dermal injury that compares to the human injury. Dermal exposures were conducted by either a flow-past or static vapor cup system. Ocular exposures were conducted by a static exposure system. Ocular and dermal exposures were conducted with vaporized SM. Vapor concentrations increased with time in the dermal and ocular exposure systems but were stable with varying amounts of applied SM. A dermal deposition estimation study was also conducted. Deposited volumes increased with exposure time.

Language: en