Citation

Kyomen HH, Satlin A, Hennen J, Wei JY. Am. J. Geriatr. Psychiatry 1999; 7(4): 339-348.

Affiliation

Harvard Medical School, Division on Aging, Consolidated Department of Psychiatry, Boston, MA, USA.

Copyright

(Copyright © 1999, American Association for Geriatric Psychiatry, Publisher Elsevier Publishing)

DOI

unavailable

PMID

10521168

Abstract

The authors used a randomized, double-blind, placebo-controlled clinical trial study design to investigate the efficacy and safety of short-term estrogen therapy in decreasing aggressive behaviors in elderly patients with moderate-to-severe dementia. Estrogen therapy was associated with lower total aggression scores (P<0.030) and with decreased frequency of physical aggression (P<0.019) over the 4-week trial. Verbally aggressive behaviors were decreased relative to control subjects, although this effect was not statistically significant. No drug-vs.-placebo differences were found for resistive, sexual, or self-directed aggressive behaviors. No adverse effects from the estrogen were observed during the course of the study.

Language: en