Citation

Bignami G, Laviola G, Alleva E, Cagiano R, Lacomba C, Cuomo V. Toxicol. Lett. 1992; 64-65 Spec No: 231-237.

Affiliation

Laboratory of Pathophysiology, Istituto Superiore di Sanità, Roma, Italy.

Copyright

(Copyright © 1992, Elsevier Publishing)

DOI

unavailable

PMID

1471179

Abstract

Previous work on the developmental aspects of neurobehavioural toxicity in rats and mice has shown the reliability of a variety of procedures aimed at assessing changes that may have widespread functional consequences, for example: (i) modified Fox batteries to study the maturation of various reflexes and responses after birth, (ii) activity/habituation and analgesia tests with age-specific profiles of reactivity to selected drug challenges, and (iii) simple learning tasks such as active and passive avoidance [1]. We will now summarize more recent work on other portions of the behavioural repertoire which deserve to be thoroughly assessed in "higher-tier" studies.

Language: en