Citation

Sladowska H, Bartoszko-Malik A, Zawisza T. Farmaco 1990; 45(1): 111-121.

Affiliation

Department of Chemistry of Drugs, School of Medicine, Wroclaw, Tamka, Poland.

Copyright

(Copyright © 1990, Elsevier Publishing)

DOI

unavailable

PMID

2337442

Abstract

Condensation of diethyl 2-amino-6-methylpyridine-3,4-dicarboxylate (I) with the corresponding isothiocyanates afforded derivatives of ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido [2,3-d]pyrimidine-5-carboxylate (V-VII). Alkylation of (V), (VI) and (XI) gave the corresponding derivatives of ethyl 2-alkylthio-4-oxo-3,4-(and 1,4)-dihydropyrido[2,3-d]pyrimidine-5- and -6- carboxylate [(XII-XVI), (XX-XXII)]. Some of the obtained compounds were active pharmacologically.

Language: en