Citation

Felip CM, Rodríguez-Arias M, Espejo EF, Miñarro J, Stinus L. Behav. Neurosci. 2000; 114(2): 424-430.

Affiliation

Area de Psicobiología, Facultad de Psicología, Universitat de Valencia, Spain.

Copyright

(Copyright © 2000, American Psychological Association)

DOI

unavailable

PMID

10832802

Abstract

The purpose of this study was to determine whether an environment associated with naloxone-induced morphine withdrawal affects aggressive or social behaviors in postdependent mice. Morphine-dependent or saline-treated mice received 3 naloxone injections in 1 of 2 different environments (A or B); 15 days afterward, when the mice were completely drug free, an aggression test was carried out in Environment A. All the mice suffering morphine withdrawal showed a significant increase in aggression, irrespective of the environment in which the withdrawal took place. In these conditions, the impact of morphine dependence and the 3 induced withdrawals was so profound that the environment could not be discriminative. In addition, modifications in the behavioral profile of postdependent mice that suffered only spontaneous withdrawal were long-lasting, with the mice carrying out more attacks during social investigation without presenting threat postures.

Language: en