Citation

Sosnowski TR, Podgorski A. Int. J. Occup. Safety Ergonomics 1999; 5(3): 431-447.

Affiliation

Warsaw University of Technology, Poland. podgorsa@ichip.pw.edu.pl.

Copyright

(Copyright © 1999, Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy, Publisher Informa - Taylor and Francis Group)

DOI

unavailable

PMID

10602658

Abstract

Physicochemical techniques used for evaluating the pulmonary surfactant (PS) quality are discussed as methods useful in assessing toxicity of inhaled gases and particles. Two standard devices, Langmuir-Wilhelmy film balance and pulsating bubble apparatus, are presented in detail, and the measured results of interaction between sulfuric acid and 2 models of PS materials are analyzed. The evident decrease in surface activity of the pulmonary surfactant after its contact with the acid at concentrations approaching 0.001 M may be considered as an indicator of the adverse effect, which can result in several health problems. The presented approach can be used as a method of assessing pulmonary toxicity of any substances present in the breathing air.

Language: en