Citation

Ruppel RA, Clark RSB, Bayir H, Satchell MA, Kochanek PM. Neurosurg. Clin. N. Am. 2002; 13(2): 169-82, v.

Affiliation

Department of Anesthesiology and Critical Care Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

Copyright

(Copyright © 2002, Elsevier Publishing)

DOI

unavailable

PMID

12391702

Abstract

A number of critical mechanisms are involved in the pathophysiology of inflicted head injury. Excitotoxicity, oxidative stress, inflammation, programmed cell death, and mediators of blood flow and metabolism all contribute to secondary injury after abusive head trauma. These mechanisms are reviewed and the implications for clinical practice discussed.

Language: en