Citation

Vishnivetskaia GB, Pliusnina IZ, Popova NK. Zh. Vyssh. Nerv. Deiat. Im. I P Pavlova 2001; 51(6): 704-708.

Vernacular Title

Uchastie 5-HT1A-resteptorov v reguliatsiia raznykh vitov agressivnogo povedeniia.

Affiliation

Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk.

Copyright

(Copyright © 2001, MAIK Nauka/Interperiodica)

DOI

unavailable

PMID

11871034

Abstract

We studied the effects of selective agonists of 5-HT1A receptors 8-OH-DPAT and flesinoxan on aggressive behavior of C57BL/6 male mice in the "resident-intruder" test and on defensive aggression of Norway rats toward man. 8-OH-DPAT (0.4 mg/kg, i.p.) significantly reduced the intermale aggression in mice and defensive aggression in rats (0.1-0.5 mg/kg, i.p.). In the dose of 0.5 mg/kg, flesinoxan inhibited the aggressive behavior in mice. These results suggest that activation of 5-HT1A receptors reduces different kinds of affective aggression. The results are discussed in terms of interaction between the well-known anxiolytic effects of 5-HT1A agonists and their antiaggressive properties.

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