Citation

De Bellis MD, Keshavan MS, Harenski KA. J. Child Adolesc. Psychopharmacol. 2001; 11(3): 311-316.

Affiliation

Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pennsylvania 15213, USA. debellismd@msx.upmc.edu

Copyright

(Copyright © 2001, Mary Ann Liebert Publishers)

DOI

10.1089/10445460152595649

PMID

11642482

Abstract

Posttraumatic stress disorder in maltreated children is associated with dysregulation of biological stress systems, adverse brain development, and neuronal loss in the anterior cingulate region of the medial prefrontal cortex. A maltreated boy with posttraumatic stress disorder was followed prospectively using single voxel proton magnetic resonance spectroscopy measures of anterior cingulate N-acetylaspartate/creatine ratios, a marker of neural integrity. N-acetylaspartate/creatine ratios increased, and sleep measures improved upon symptom remission.

Language: en