Citation

Sukhotina IA. Pharmacol. Biochem. Behav. 2001; 68(1): 93-98.

Affiliation

Laboratory of Behavioural Pharmacology, Department of Psychopharmacology, Valdman Institute of Pharmacology, Pavlov Medical University, 6/8 Lev Tolstoy Street, St. Petersburg 197089, Russia. behav@spmu.rssi.ru

Copyright

(Copyright © 2001, Elsevier Publishing)

DOI

unavailable

PMID

11274713

Abstract

There is a considerable body of evidence indicating that stimuli associated with drug administration may become conditioned and evoke drug-like effects. The purpose of this study was to evaluate the ability of morphine-paired stimuli to affect an expression of morphine withdrawal-facilitated aggression. Individually housed aggressive adult mice were subjected to the repeated subcutaneous administration of morphine (twice a day, 8 days, increasing doses 10-80 mg/kg). Morphine treatment cessation facilitated an aggressive behaviour of animals during the second day of withdrawal. Subcutaneous but not intraperitoneal injection of saline attenuated the aggressive behaviour in morphine-withdrawn mice. These results suggest that the site of drug injection may serve as a conditioned stimulus.

Language: en