Citation

Saudou F, Amara DA, Dierich A, LeMeur M, Ramboz S, Segu L, Buhot MC, Hen R. Science 1994; 265(5180): 1875-1878.

Affiliation

Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U184 de l'INSERM, Faculté de Médecine, Strasbourg, France.

Copyright

(Copyright © 1994, American Association for the Advancement of Science)

DOI

unavailable

PMID

8091214

Abstract

The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT1B receptor were generated by homologous recombination. These mice did not exhibit any obvious developmental or behavioral defects. However, the hyperlocomotor effect of the 5-HT1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, mutant mice attacked the intruder faster and more intensely than did wild-type mice, suggesting the participation of 5-HT1B receptors in aggressive behavior.

Language: en