Citation

Dougherty DD, Bonab AA, Ottowitz WE, Livni E, Alpert NM, Rauch SL, Fava M, Fischman AJ. Depress. Anxiety 2006; 23(3): 175-177.

Affiliation

Department of Psychiatry, Massachusetts General Hospital, Boston, USA. ddougherty@partners.org

Copyright

(Copyright © 2006, John Wiley and Sons)

DOI

10.1002/da.20168

PMID

16528700

Abstract

This study assessed striatal dopamine 1 (D1) receptor binding in patients with major depressive disorder and anger attacks (MDD+A) and healthy volunteers. We used positron emission tomography with [(11)C]SCH 23,390 to compare 10 patients with MDD+A to 10 healthy volunteers. [(11)C]SCH 23,390 binding in bilateral striata was significantly lower in the MDD+A group when compared to healthy volunteers. These results implicate striatal D1 receptor dysfunction in MDD+A and further suggest an association between dopaminergic transmission and anger or aggression.

Language: en