Citation

Beer C, Hyde Z, Almeida OP, Norman P, Hankey GJ, Yeap BB, Flicker L. Br. J. Clin. Pharmacol. 2011; 71(4): 592-599.

Affiliation

Western Australian Centre for Health and Ageing, Centre for Medical Research, Western Australian Institute for Medical Research School of Medicine and Pharmacology School of Psychiatry and Clinical Neurosciences School of Surgery, University of Western Australia Department of Geriatric Medicine Department of Psychiatry Stroke Unit, Royal Perth Hospital Department of Endocrinology and Diabetes, Fremantle Hospital, Perth, WA, Australia.

Copyright

(Copyright © 2011, John Wiley and Sons)

DOI

10.1111/j.1365-2125.2010.03875.x

PMID

21395652

PMCID

PMC3080648

Abstract

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Adverse drug reactions and polypharmacy are common, particularly later in life. Suboptimal use of medicines may be associated with adverse health outcomes. WHAT THIS STUDY ADDS • Markers of potentially suboptimal medication use (both medication over-use and under-use) were observed frequently among a cohort of community dwelling older men. Potentially suboptimal medication appeared to be independently associated with important adverse health outcomes. AIM To determine the prevalence of potentially suboptimal medication use and association with adverse outcomes. METHODS A prospective, observational cohort study of 4260 community-dwelling older men from Perth, Western Australia (mean age of 77 ± 3.6 years) was conducted. Follow-up was for 4.5 years (or until death, if sooner). Cox proportional hazard models were used to explore associations between suboptimal medication use and prospective clinical outcomes. Logistic regression analyses were used to explore predictors of a fall in the previous 12 months. RESULTS Use of potentially inappropriate medicines (48.7%), polypharmacy (≥5 medications, 35.8%) and potential under-utilization (56.7%) were highly prevalent, and overall 82.3% of participants reported some form of potentially suboptimal medication use. A self-reported history of falls in the previous 12 months was independently associated with the number of medicines taken (odds ratio [OR]= 1.06, 95% confidence interval [CI] 1.02, 1.09) and use of one or more potentially inappropriate medicines (OR = 1.23, 95% CI 1.04, 1.45). After adjusting for age, co-morbidity, smoking status, body mass index, hypertension and educational attainment, the number of medicines reported was associated with admission to hospital (hazard ratio [HR]= 1.04, 95% CI 1.03, 1.06), cardiovascular events (HR = 1.09, 95% CI 1.06, 1.12) and all cause mortality (HR = 1.04, 95% CI 1.00, 1.07). Use of one or more potentially inappropriate medicines was associated with admission to hospital (HR = 1.16, 95% CI 1.08, 1.24). Potential under-utilization was associated with cardiovascular events (HR = 1.20, 95% CI 1.03, 1.40). CONCLUSIONS These data suggest that both medication over-use and under-use occur frequently among older men and may be harmful.

Language: en