Citation

Frink M, Andruszkow H, Zeckey C, Krettek C, Hildebrand F. J. Biomed. Biotechnol. 2011; 2011(online): 797383.

Affiliation

Trauma Department, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

Copyright

(Copyright © 2011, Hindawi Publishing)

DOI

10.1155/2011/797383

PMID

21331361

PMCID

PMC3035380

Abstract

Treatment of polytrauma patients remains a medical as well as socioeconomic challenge. Although diagnostics and therapy improved during the last decades, multiple injuries are still the major cause of fatalities in patients below 45 years of age. Organ dysfunction and organ failure are major complications in patients with major injuries and contribute to mortality during the clinical course. Profound understanding of the systemic pathophysiological response is crucial for innovative therapeutic approaches. Therefore, experimental studies in various animal models are necessary. This review is aimed at providing detailed information of common trauma models in small as well as in large animals.

Language: en