Citation

Mattila M. Proc. Int. Counc. Alcohol Drugs Traffic Safety Conf. 1981; 1981: 909-922.

Copyright

(Copyright © 1981, The author(s) and the Council, Publisher International Council on Alcohol, Drugs and Traffic Safety)

DOI

unavailable

PMID

unavailable

Abstract

Various attempts to counteract acute etoh effects have not been rewarding so far. Various reports from animal experiments suggest that etoh sleep or etoh anaesthesia is effectively counteracted with various more or less non-specific stimulants, but these results refer to heavy etoh intoxication only. An altered turn-over of various brain neurotransmitters, well documented in animals, may not be an important contributor to inebriation but is rather associated with etoh inebriation in a non-specific way. One may conclude that there is no relevant animal behaviour model that matches the subtle central depression after low doses of etoh. Etoh acts as a solvent which impairs various membrane functions, and a really effective specific antagonist would be hard to find. (Author/TRRL)