Citation

Jouglard J, Perringue C, Goujard J, Servetti A, David JM. Therapie 1996; 51(5): 582-585.

Vernacular Title

Evaluation par les centres anti-poisons de la toxicite de la minaprine depuis la

Affiliation

Centre antipoisons de Marseille-Hôpital Salvator.

Copyright

(Copyright © 1996, John Libbey Eurotext)

DOI

unavailable

PMID

9138401

Abstract

By 1990, the Clin Midy (SANOFI) laboratory had modified the dose of Cantor tablets: the content of active drug (minaprine) increased (50 to 100 mg). Therefore, acute intoxication by minaprine can be serious, with generalized seizures, resisting the classic treatment. We tried to evaluate the possible consequences of this change of dose for the gravity of suicide attempts. 1091 voluntary acute intoxications have been collected by the national French Poisons Centres data bank, 226 of them by the Poisons center of Marseilles. We have compared, by the chi 2 method, the frequencies of seizure and death, before and after 1990. Results are significant, confirming an increased gravity of these intoxications since the modification of dosage. Then, the laboratory reduced the number of tablets per box. We don't know if this measure will be efficient.

Language: fr