Citation

Wang Y, Zhang J, Li X, Ji J, Yang F, Wan C, Feng G, Wan P, He L, He G. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008; 32(8): 1902-1904.

Affiliation

Bio-X Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China.

Copyright

(Copyright © 2008, Elsevier Publishing)

DOI

10.1016/j.pnpbp.2008.09.003

PMID

18812204

Abstract

BACKGROUND: Bipolar disorder (BPD) is a common, severe and recurrent psychiatric disorder. It has been suggested that BPD patients have a higher risk of suicide than patients with any other psychiatric illnesses. A recent study found that suicide attempt was associated with the SCN8A gene, which has been mapped close to one of the BPD susceptibility loci. Thus, SCN8A is likely to be a candidate gene for BPD. METHODS: In this study, three SNPs (rs1601012, rs303810, rs60637) were analyzed in 506 bipolar patients and 507 controls of Han origin. RESULTS: We found that two individual SNPs showed statistically significant differences between cases and controls in both allele and genotype distribution, but only rs303810 was still significant in allele distribution (p=0.0164) after correction. No obvious linkage disequilibrium or haplotypes were observed among these SNPs. CONCLUSION: Our results indicate that SCN8A may be a potential susceptibility gene for bipolar disorder in the Han Chinese population.

Language: en