Citation

Staikowsky F, Theil F, Candella S. Presse Med. (1983) 2005; 34(12): 842-846.

Vernacular Title

Evolution des medicaments utilises dans les intoxications medicamenteuses

Affiliation

Service des Urgences, CHU Tenon, Paris. frederik.staikowsky@wanadoo.fr

Copyright

(Copyright © 2005, Elsevier Publishing)

DOI

unavailable

PMID

16097205

Abstract

OBJECTIVES: The aim of the study was to investigate trends in substances used for acute self-administered drug overdoses (SADO). METHOD: Review of all SADO emergency room visits over two 1-year periods during 1992-1993 (P1) and 2001-2002 (P2). RESULTS: We compared 804 SADO episodes in P1 with 830 in P2. Patient characteristics did not differ significantly during the two periods (predominance of women: 66 vs 69%; mean age: 33 +/- 12 vs 37 +/- 13.5 years). Psychotropic drugs predominated in both periods (78 and 77%), but the prevalence of benzodiazepines declined (67 to 55%; p < 0.01) and that of antidepressants increased (9.5 to 15%; p < 0.01). Bromazepam was the ben-zodiazepine used most often during both periods (P1: 30% and P2: 35%), but the use of aprazolam increased (from 6 to 17%; p < 0.01). Among the antidepressants, the use of tricyclics decreased (from 43 to 14%; p < 0.01) and that of selective serotonin reuptake inhibitors increased (31 to 71%; p < 0.01). The proportion of benzodiazepine-related drugs increased over time (8.1 to 14%: p < 0.01). The other therapeutic classes remained quite similar to each other between P1 and P2, except for anti-inflammatories (P1: 1.3%, P2: 2.7%; p = 0.01). Among the analgesics, paracetamol alone or combined with other agents predominated (68 and 64% respectively), but use of opiate analgesics was fre-quent during the later period (2.7 vs 22%; p < 0.01). CONCLUSION: The trend of the different pharmacological families used in SADO seen in the emergency room has not fundamentally changed over the past decade. However, qualitative changes within the drug classes require emergency physicians to update their knowledge of toxicology.

Language: fr