Citation

Gallo C, Orlassino R, Vineis C. Pathologica 2006; 98(1): 44-47.

Vernacular Title

Emorragie intracerebrali ricorrenti in paziente con angiopatia cerebrale

Affiliation

U.O.A. di Anatomia Patologica ed Istocitopatologia, Ospedale Civile di Ivrea, Ivrea, TO, Italia.

Copyright

(Copyright © 2006, Società Anatomo Patologi Ospedalieri Italiani, Publisher Ospedali Galliera di Genova)

DOI

unavailable

PMID

16789686

Abstract

Cerebral amyloidotic angiopathy represents the most frequent cause of lobar haematoma in young patients and represents 5-10% of the non-traumatic cerebral haemorrhages. In the present work, we describe one autoptic case of recurrent cerebral haemorrhages in a 58-year-old woman. Macroscopically in the brain multiple haemorragic areas were present in the right frontal pole, right frontal and temporo-parietal lobes with homolateral ventricular inundation. The histological, histochemical, immunohistochemical, ultrastructural and biomolecular investigations confirmed the presence of amyloid deposits in the middle-size and little-size cerebral arteries. We report, moreover, a novel mutation (Leu705Val) within the Abeta sequence of a AbetaPP in a family with autosomal dominant, recurrent intracerebral hemorrhages beginning in the sixth decade of life.

Language: it