Citation

Lowther S, Katona CL, Crompton MR, Horton RW. Mol. Psychiatry 1997; 2(4): 314-321.

Affiliation

Department of Pharmacology and Clinical Phamacology, St George's Hospital Medical School, London, UK. slowther@sghms.ac.uk

Copyright

(Copyright © 1997, Nature Publishing Group)

DOI

unavailable

PMID

9246672

Abstract

5-HT1D and 5-HT1E/1F receptor binding sites were measured in brain samples obtained at postmortem from suicide victims with a firm retrospective diagnosis of depression, and matched controls. In antidepressant-free suicides a significantly higher number of 5-HT1D receptors was found in globus pallidus. This was largely restricted to those suicides who died by violent means. This effect was not observed in antidepressant-treated suicides. No differences or trends in 5-HT1D binding were found in putamen, parietal or frontal cortex, in antidepressant-free or antidepressant-treated suicides. There were no differences in the number of 5-HT1E/1F receptors in any of the regions studied.

Language: en