Citation

Azaroual N, Imbenotte M, Cartigny B, Leclerc F, Vallée L, Lhermitte M, Vermeersch G. MAGMA 2000; 10(3): 177-182.

Affiliation

Laboratoire de Physique, UPRESA CNRS 8009, Laboratoire d'Application RMN de l'Universit¿ de Lille 2, BP 83, 59006 Cedex, Lille, France.

Copyright

(Copyright © 2000, Springer)

DOI

unavailable

PMID

10873209

Abstract

Analysis of biological fluids by proton and carbon nuclear magnetic resonance spectroscopy (1H and 13C NMR) is a promising tool in clinical biology. We used this method for rapid toxicological screening in the case of two suicide attempts. For each case, a urine sample was analysed at 300 MHz by 1D and 2D sequences (TOCSY and HMBC) in a short experimental time. Quantification was performed by peak integration on the 1D 1H NMR spectrum. For the two patients, results showed the same resonances of the major metabolite, valproyl-O-glucuronide at concentrations of 121 and 44 mmol/l.

Language: en