Citation

Krüger C, Jüngert J, Schmitt-Grohe S, Beese M, Ruder H. Klin. Padiatr. 1998; 210(3): 136-138.

Vernacular Title

Azathioprin-Ingestion in suizidaler Absicht bei einem Jugendlichen mit juveniler

Affiliation

Klinik mit Poliklinik für Kinder und Jugendliche, Universität Erlangen-Nürnberg.

Copyright

(Copyright © 1998, Ferdinand Enke Verlag)

DOI

10.1055/s-2008-1043866

PMID

9629549

Abstract

We report on a 13 years 7 months old boy who ingested 650 mg azathioprine in a suicide attempt. His baseline medication was azathioprine and methotrexate for control of juvenile chronic polyarthritis. After the induction of vomiting by ipecacuanha sirup and administration of charcoal (1 g/kg), he was closely followed for haematological, hepatic, and renal side effects. During the following days, no serious adverse events were noted except that the thrombocyte (from 403,000 down to 199,000/microliter) and total leukocyte count decreased moderately (from 12,000 down to 7100/microliter). On the basis of this case report and the available literature, the potential acute toxicity of azathioprine and possible treatment modalities are discussed.

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