Citation

Saito T, Morita S, Motojyuku M, Akieda K, Otsuka H, Yamamoto I, Inokuchi S. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2008; 875(2): 573-576.

Affiliation

Department of Emergency and Clinical Care Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan. saito@is.icc.u-tokai.ac.jp

Copyright

(Copyright © 2008, Elsevier Publishing)

DOI

10.1016/j.jchromb.2008.10.002

PMID

18945651

Abstract

A rapid headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) method has been developed for the determination of metaldehyde in human serum samples. Metaldehyde is extensively used as a molluscicide for the control of slugs and snails, and cases of metaldehyde poisoning have been reported. Metaldehyde was headspace-extracted on a polydimethylsiloxane (PDMS) fiber at 70 degrees C for 25 min, desorbed, and analyzed rapidly by GC-MS. The method was validated for limit of detection (LOD), linearity, precision, and recovery. Although the recovery of the sample was very low, the method itself was rapid with a low detection limit of 0.25 microg/ml, R.S.D. value 12.6%, and linearity range 0.5-25.0 microg/ml (r(2)=0.999). The results demonstrated that the SPME-GC-MS method for the analysis of metaldehyde is simple, rapid, solvent-free, and does not require any pre-analysis conversions.

Language: en