Citation

Leonard HL, Topol D, Bukstein O, Hindmarsh D, Allen AJ, Swedo SE. J. Am. Acad. Child Adolesc. Psychiatry 1994; 33(6): 792-794.

Affiliation

Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892.

Copyright

(Copyright © 1994, American Academy of Child Adolescent Psychiatry, Publisher Lippincott Williams and Wilkins)

DOI

10.1097/00004583-199407000-00003

PMID

8083135

Abstract

This case study is of a young man with childhood onset of severe obsessive-compulsive disorder (OCD). The patient had no clinical improvement during therapeutic trials of clomipramine, fluoxetine, and fluvoxamine, including buspirone augmentation. The patient consumed 50 tablets of fluoxetine in a suicide attempt and experienced a total remission of his OCD symptoms for the first time in his life. This remission lasted approximately 1 month and raises interesting questions about the mechanism of action of the serotonin reuptake inhibitors. Subsequently, the patient was able to achieve a 75% improvement in symptomatology when treated with a combination of fluoxetine and clonazepam. This open report suggests that clonazepam may be an effective augmentation agent to a serotonin reuptake inhibitor in the treatment of OCD.

Language: en