Citation

Hantson P, Verellen-Dumoulin C, Libouton JM, Leonard A, Leonard ED, Mahieu P. Int. Arch. Occup. Environ. Health 1996; 68(5): 342-344.

Affiliation

Department of Intensive Care Medicine, Cliniques Universitaires St-Luc, Brussels, Belgium.

Copyright

(Copyright © 1996, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

8832300

Abstract

OBJECTIVE: To evaluate the cytogenetic effects following the ingestion of high doses of arsenicals. METHODS: Determination of the mean sister chromatid exchange (SCE) frequency and the population of high-frequency cells (HFC, cells with a high SCE frequency) in the peripheral blood lymphocytes in four patients who ingested 150 mg KAsO2, 1 g, 10 g and 20 g As2O3 respectively. RESULTS: Doses of 10 g and 20 g significantly increased the HFC frequency and produced a shift in the distribution of the cells in accordance with the number of SCEs. The mean frequency of SCEs/cell was affected only after the highest dose (20 g). CONCLUSION: These results strongly suggest that cytogenetic methods are inappropriate for biomonitoring people occupationally exposed to arsenicals.

Language: en