Citation

Bowden C, Cheetham SC, Lowther S, Katona CL, Crompton MR, Horton RW. Eur. Neuropsychopharmacol. 1997; 7(4): 247-252.

Affiliation

Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, UK.

Copyright

(Copyright © 1997, Elsevier Publishing)

DOI

unavailable

PMID

9443655

Abstract

We have quantitated dopamine uptake sites, labelled with [3H]GBR12935, in caudate, putamen and nucleus accumbens of suicides with a retrospective diagnosis of depression, and age and gender-matched controls. Suicides were subdivided into those who had been free of antidepressant drugs for at least three months, and those in whom prescription of antidepressant drugs was clearly documented. We found no significant differences between controls and suicides overall, or when the suicides were divided on the basis of antidepressant treatment or violence of death. A significant negative correlation between the number of dopamine uptake sites and age was found in each region studied. Our results suggest dopamine uptake sites are not critically involved in depression or antidepressant drug action.

Language: en