Citation

Gross-Isseroff R, Weizman A, Fieldust SJ, Israeli M, Biegon A. Eur. Neuropsychopharmacol. 2000; 10(4): 265-271.

Affiliation

Department of Neurobiology, The Weizman Institute of Science, 76100, Rehovot, Israel. bmruth@weizmann.weizmann.ac.il

Copyright

(Copyright © 2000, Elsevier Publishing)

DOI

unavailable

PMID

10871708

Abstract

In vitro quantitative autoradiography of alpha(2)-adrenergic/imidazoline receptors, using [(125)I]iodoclonidine as a ligand, was performed on 24 human brains postmortem. Twelve brains were obtained from suicide victims and 12 from matched controls. We found no significant, region-dependent alterations in the density of alpha(2)-adrenergic receptors in brains of suicide victims as compared to matched controls. We also report age-dependent reductions in binding in the prefrontal cortex and hippocampus, as well as significant recent alcohol ingestion-dependent reductions in binding in the prefrontal cortex. Sex and time from death to autopsy did not affect iodoclonidine binding in our sample.

Language: en