Citation

Brandt C, Elsner H, Füratsch N, Hoppe M, Nieder E, Rambeck B, Ebner A, May TW. Epilepsia 2010; 51(6): 1090-1093.

Affiliation

Bethel Epilepsy Centre, Department of General Epileptology, Bielefeld, Germany.

Copyright

(Copyright © 2010, John Wiley and Sons)

DOI

10.1111/j.1528-1167.2009.02395.x

PMID

19889015

Abstract

We report the case of a 21-year-old man with idiopathic generalized epilepsy who ingested about 8,000 mg of topiramate (TPM) in a suicide attempt. On admission to the hospital he had a nonconvulsive status epilepticus and received 4 mg lorazepam i.v. He recovered rapidly despite an initial TPM concentration of 144.6 microg/ml. To our knowledge, this is the first report of a patient who survived such a high TPM concentration. The case indicates that nonconvulsive status epilepticus could be a manifestation of TPM intoxication.

Language: en