Citation

Enders SJ, Enders JM. Ann. Pharmacother. 2003; 37(7-8): 1124-1127.

Affiliation

Division of Pharmacy Practice, St. Louis College of Pharmacy, St. Louis, MO 63110-1088, USA. senders@stlcop.edu

Copyright

(Copyright © 2003, Harvey Whitney Books)

DOI

unavailable

PMID

12841827

Abstract

OBJECTIVE: To evaluate the relationship between isotretinoin and psychiatric illness in adolescents and young adults. DATA SOURCES: Primary literature located via MEDLINE (1966-December 2002). Key terms were isotretinoin, depression, psychosis, suicide, and adolescents. DATA SYNTHESIS: Information regarding depression was added to isotretinoin labeling in 1998 following a series of case reports and submitted to the MedWatch system. CONCLUSIONS: Although a causal relationship may exist between isotretinoin and psychiatric illness in adolescents and young adults, this has not been demonstrated in the literature. Until evidence establishes a presence or lack of causality, prescribers should exercise caution when treating adolescents and young adults with isotretinoin.

Language: en