Citation

Leventhal LJ, Kochar G, Feldman NH, Podolsky SM, Stanek MS. Am. J. Emerg. Med. 1989; 7(4): 417-418.

Affiliation

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.

Copyright

(Copyright © 1989, Elsevier Publishing)

DOI

unavailable

PMID

2567599

Abstract

An 18-year-old man with theophylline overdose developed an increased anion gap metabolic acidosis. Serum lactate levels were markedly elevated. A direct correlation was found between the increasing theophylline level, clinical hyperadrenergic state, and the worsening acidosis. Early hemoperfusion reversed the acidosis, the elevated serum theophylline level, and the hyperadrenergic state. This case substantiates the role of lactate accumulation in the metabolic acidosis associated with isolated theophylline toxicity.

Language: en