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Abstract
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Twenty three cases of acute para-phenylenediamine poisoning were examined clinically at emergency ward of Rama Medical College Hospital, Kanpur (Uttar Pradesh) irrespective of age, sex and socio-economic strata along with route and manner of administration of the poison.
Albuminuria, anaemia, hypocalcemia, leucocytosis, thrombocytopenia, increased serum bilirubin, prolonged bleeding and clotting time alongwith increased levels of liver enzymes and serum creatinine were observed as significant bio-chemical parameters; on investigation in respect to complete haemogram, liver function test, renal function test, serum electrolytes, serum CPK levels and arterial blood gas analysis.
The para-phenylenediamine is the ingredient of a traditional cosmetic hair dye available with the trade name Godrej expert powder hair dye, which is orally administered mainly with an intention to commit suicide, sometimes accidentally and very rarely as homicidal poison by hair dye users. The suicidal poisoning is more common in females as compared to males. The systemic toxicity of PPD has serious consequences which may eventually lead to death.
The cases are reported with the advice “public education and strict control over the sale and distribution of para-phenylenediamine should be done to reduce poisoning by this agent”.
Key Words: Para-Phenylenediamine, Suicidal Poisoning, Traditional Cosmetic, Hair Dye |