Citation

Ramasamy A, Masouros SD, Newell N, Hill AM, Proud WG, Brown KA, Bull AMJ, Clasper JC. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2011; 366(1562): 160-170.

Affiliation

Imperial Blast Biomechanics and Biophysics Group, 4.28 Royal School of Mines, Imperial College London, , London SW7 2AZ, UK.

Copyright

(Copyright © 2011, Royal Society of London)

DOI

10.1098/rstb.2010.0219

PMID

21149353

PMCID

PMC3013426

Abstract

The conflicts in Iraq and Afghanistan have been epitomized by the insurgents' use of the improvised explosive device against vehicle-borne security forces. These weapons, capable of causing multiple severely injured casualties in a single incident, pose the most prevalent single threat to Coalition troops operating in the region. Improvements in personal protection and medical care have resulted in increasing numbers of casualties surviving with complex lower limb injuries, often leading to long-term disability. Thus, there exists an urgent requirement to investigate and mitigate against the mechanism of extremity injury caused by these devices. This will necessitate an ontological approach, linking molecular, cellular and tissue interaction to physiological dysfunction. This can only be achieved via a collaborative approach between clinicians, natural scientists and engineers, combining physical and numerical modelling tools with clinical data from the battlefield. In this article, we compile existing knowledge on the effects of explosions on skeletal injury, review and critique relevant experimental and computational research related to lower limb injury and damage and propose research foci required to drive the development of future mitigation technologies.

Language: en